django-dbdiff was released. It allows to exclude fields from tests with the new exclude parameter, ie::
Fixture( 'tweets/tests/after_create_retweet.json', models=[Tweet, Retweets], ).assertNoDiff( exclude={ 'tweets.tweet': ['datetime'], 'tweets.retweets': ['datetime'], }, } This was initially requested by Nicolas Joyard for the Political Memory project.
Note that you shouldn’t use exclude for datetimes like in the above example, but instead use something like freezegun to force datetimes to an arbitrary fixture.